Correlation of Hyperglycemia with Rosacea

Authors

  • Bnar S.M. Amin 1. MBChB, KBMS Trainee , Sulaimani Teaching center for Dermatological diseases , Sulaimani, Kurdistan region/Iraq
  • Ali Mozan Dhahir El-Ethawi M.B.Ch.B, FIBMS (Derm.), CABD, Professor of dermatology, Collage of Medicine, University of Sulaimani

Keywords:

Rosacea, Blood sugar, Diabetes mellitus

Abstract

Background: The roscaea is a common chronic facial skin disease that affects predominantly Iraqi women. Although the pathogenesis of roscaea is unclear, many systemic co-morbidities are thought to play a major role in development of rosacea.

Objective: To assess the correlation between hyperglycemia and rosacea.

Patients & Methods: A cross sectional study carried out in Sulaimani Teaching center for Dermatological diseases in Sulaimani city-Kurdistan region/Iraq during the period, August 2019 to February, 2020 included 40 patients with proved diagnosed roscaea and 40 healthy controls. Diagnosis of roscaea was according to the National Roscaea Society Expert Committee. Laboratory parameters , fasting blood glucose, HbA1c and glucose intolerance test performed at private laboratory center.

Results: The mean age of roscaea patients was (50.2 years) and female to male ratio was 2.3:1. Common type of roscaea observed was Erythemotelengectatic type (52.2%). A highly significant association between positive history of diabetes mellitus and roscaea (p<0.001). Mean fasting blood sugar of roscaea patients was significantly higher than that in controls (p=0.001).

Conclusions: High fasting blood sugar level increases susceptibility to roscaea development that may suggests the link between roscaea and diabetes mellitus in addition to an obvious relationship between positive family history of diabetes mellitus and roscaea incidence..

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References

Yuan X, Huang X, Wang B, Huang YX, Zhang YY, Tang Y, et al Relationship between rosacea and dietary factors: A multicenter retrospective case-control survey. J Dermatol 2019; 46(3):219-225.

Steinhoff M, Schauber J, Leyden JJ. New insights into rosacea pathophysiology: a review of recent findings. J Am Acad Dermatol 2013; 69(6 Suppl 1):S15-26.

Wilkin J, Dahl M, Detmar M, Drake L, Feinstein A, Odom R, et al. Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol 2002; 46(4):584-587.

Gallo RL, Granstein RD, Kang S, Mannis M, Steinhoff M, Tan J, et al. Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee. J Am Acad Dermatol 2018; 78(1):148-155.

Tan J, Almeida LM, Bewley A, Cribier B, Dlova NC, Gallo R, et al. Updating the diagnosis, classification and assessment of rosacea: recommendations from the global ROSacea COnsensus (ROSCO) panel. Br J Dermatol 2017; 176(2):431-438.

Kawen AA, Al-Sultany HA. Clinical Variants of Rosacea in Iraqi Patients. Medico-legal Update 2020; 20 (3): 616-620.

Ahn CS, Huang WW. Rosacea Pathogenesis. Dermatol Clin 2018; 36(2):81-86.

Rainer BM, Kang S, Chien AL. Rosacea: Epidemiology, pathogenesis, and treatment. Dermatoendocrinol 2017; 9(1):e1361574.

van Zuuren EJ. Rosacea. N Engl J Med 2017; 377(18):1754-1764.

Gravina A, Federico A, Ruocco E, Lo Schiavo A, Masarone M, Tuccillo C, et al. Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea. United European Gastroenterol J 2015; 3(1):17-24.

Marson JW, Baldwin HE. Rosacea: a wholistic review and update from pathogenesis to diagnosis and therapy. Int J Dermatol 2020; 59(6):e175-e182.

Oda E. Metabolic syndrome: its history, mechanisms, and limitations. Acta Diabetol 2012; 49(2):89–95.

Huang PL. A comprehensive defnition for metabolic syndrome. Dis Model Mech 2009; 2(5– 6):231–237.

Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet Lond Engl 2005; 365(9468):1415–1428.

Zhou S-S, Li D, Zhou Y-M, Cao J-M. The skin function: a factor of antimetabolic syndrome. Diabetol Metab Syndr 2012; 4(1):15.

Yamanaka K, Nakanishi T, Saito H, Maruyama J, Isoda K, Yokochi A, et al. Persistent release of IL-1s from skin is associated with systemic cardiovascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic infammatory diseases. PLoS ONE 2014; 9(8):e104479.

Tanmay Padhi G. Metabolic syndrome and skin: psoriasis and beyond. Indian J Dermatol 2013; 58(4):299–305.

Barrett EJ, Eggleston EM, Inyard AC. The vascular actions of insulin control its delivery to muscle and regulate the ratelimiting step in skeletal muscle insulin action. Diabetologia 2009; 52:752–764.

Ko SH, Cao W, Liu Z. Hypertension management and microvascular insulin resistance in diabetes. Curr Hypertens Rep 2010; 12:243–251.

Spoendlin J, Voegel JJ, Jick SS, Meier CR. Risk of rosacea in patients with diabetes using insulin or oral antidiabetic drugs. J Invest Dermatol 2013; 133(12):2790-2793.

Two AM, Wu W, Gallo RL, Hata TR. Rosacea: part II. Topical and systemic therapies in the treatment of rosacea. J Am Acad Dermatol 2015; 72:761-70. Available at: https://doi.org/10.1016/j.jaad.2014.08.027

van Zuuren EJ, Fedorowicz Z, Carter B, van der Linden MM, Charland L. Interventions for

rosacea. Cochrane Database Syst Rev 2015:CD003262.

Del Rosso JQ, Thiboutot D, Gallo R, Webster G, Tanghetti E, Eichenfield L, et al. Consensus recommendations from the American Acne & Rosacea Society on the management of rosacea, part 1: a status report on the disease state, general measures, and adjunctive skin care. Cutis 2013; 92:234-240.

Rivero AL, Whitfeld M. An update on the treatment of rosacea. Aust Prescr 2018; 41(1):20-24.

Sharquie KE, Najim RA, Al-Salman HN. Oral zinc sulfate in the treatment of rosacea: a double- blind, placebo-controlled study. Int J Dermatol 2006; 45(7):857-861.

Al-Dabagh A, Davis SA, McMichael AJ, Feldman SR. Rosacea in skin of color: not a rare diagnosis. Dermatol Online J 2014; 20(10):13030/qt1mv9r0ss.

Parodi A, Paolino S, Greco A, Drago F, Mansi C, Rebora A, et al. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenterol Hepatol 2008; 6(7):759-764.

Gravina A, Federico A, Ruocco E, Lo Schiavo A, Masarone M, Tuccillo C, et al. Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea. United European Gastroenterol J 2015; 3(1):17-24.

Duman N, Ersoy Evans S, Atakan N. Rosacea and cardiovascular risk factors: a case control study. J Eur Acad Dermatol Venereol 2014; 28(9):1165-1169.

Dhaher SA. Reappraisal of the Effect of Helicobacter pylori Eradication Treatment on Rosacea in Iraqi Patients. International Journal of Pharmaceutical Research ; 13 (1): 2402-2408.

Tan J, Schöfer H, Araviiskaia E, Audibert F, Kerrouche N, Berg M; RISE study group. Prevalence of rosacea in the general population of Germany and Russia - The RISE study. J Eur Acad Dermatol Venereol 2016; 30(3):428-434.

Li S, Cho E, Drucker AM, Qureshi AA, Li WQ. Obesity and risk for incident rosacea in US women. J Am Acad Dermatol 2017; 77(6):1083-1087.e5.

Kucukunal A, Altunay I, Arici JE, Cerman AA. Is the effect of smoking on rosacea still somewhat of a mystery? Cutan Ocul Toxicol 2016; 35(2):110-114.

Drago F, Ciccarese G, Herzum A, Rebora A, Parodi A. Rosacea and alcohol intake. J Am Acad Dermatol 2018; 78(1):e25.

Chen Q, Shi X, Tang Y, Wang B, Xie HF, Shi W, et al. Association between rosacea and cardiometabolic disease: A systematic review and meta-analysis. J Am Acad Dermatol 2020; 83(5):1331-1340.

Hua TC, Chung PI, Chen YJ, Wu LC, Chen YD, Hwang CY, et al. Cardiovascular comorbidities in patients with rosacea: A nationwide case-control study from Taiwan. J Am Acad Dermatol

; 73(2):249-254.

Chang ALS, Raber I, Xu J, Li R, Spitale R, Chen J, et al. Assessment of the genetic basis of rosacea by genome-wide association study. J Invest Dermatol 2015; 135(6):1548-1555.

Alexis AF, Callender VD, Baldwin HE, Desai SR, Rendon MI, Taylor SC. Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: Review and clinical practice experience. J Am Acad Dermatol 2019; 80(6):1722-1729.e7.

Akin Belli A, Ozbas Gok S, Akbaba G, Etgu F, Dogan G. The relationship between rosacea and insulin resistance and metabolic syndrome. Eur J Dermatol 2016; 26(3):260-264.

Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Clustering of autoimmune diseases in patients with rosacea. J Am Acad Dermatol 2016; 74(4):667-672.e1.

Gökçe C, Aycan-Kaya Ö, Yula E, Üstün I, Yengil E, Sefil F, et al. The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus. J Int Med Res 2013; 41(5):1752-1758.

Spoendlin J, Voegel JJ, Jick SS, Meier CR. Risk of rosacea in patients with diabetes using insulin or oral antidiabetic drugs. J Invest Dermatol 2013; 133(12):2790-2793.

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Published

2022-04-30

How to Cite

Bnar S.M. Amin, & Ali Mozan Dhahir El-Ethawi. (2022). Correlation of Hyperglycemia with Rosacea. Academic Journal of Clinicians, 4(01), 1–14. Retrieved from https://clinician.site/index.php/ajcs/article/view/1