Correlation of Myonectin Levels with Metabolic And Hormonal Disorders in Patients with Polycystic Ovary Syndrome

Abstract

Background: The Polycystic ovarian syndrome is a heterogenous collection of clinical features that, met together, form a range of illness. Myonectin is a cytokine  produced and released by myocytes throughout muscular contractions and participates in glucose and lipid metabolism .

Objective: This study aims to explore the association between myonectin levels and metabolic and hormonal parameters in women diagnosed with polycystic ovarian syndrome (PCOS).

Patients and Methods: We conducted a prospective case-control study at the Department of Obstetrics and Gynecology in Al-Imamein Al-Khademein Medical City, spanning from December 1, 2021, to December 1, 2022. The study included 140 women wjo were assigned into two groups: Cases group included 70 women with polycystic ovary syndrome identified according to Rotterdam criteria (2003), and Control group included 70 healthy women with no clinical or biochemical manifestation of polycystic ovarian disease with normal morphology of both ovaries.  Both groups were matched for age, and BMI. The clinical Data, Myonectin levels, metabolic and sex hormones , of both groups were analyzed and compared.

Results:

No significant differences regarding age and  BMI were found, (P. value>0.05). The mean Myonectin level in case group is (6.7± 2.3) ng/ml which is significantly lower than levels in control group (9.5±2.7) ng/ml at (P-value <0.001). In PCOS group, Myonectin levels had significant negative correlation with FBS, HOMA-IR ,Triglyceride,testosterone and positive significant correlation with SHBG and HDL.

Conclusion:

Myonectin levels were significantly decreased in patients with polycystic ovarian disease and were significantly correlated with metabolic and hormonal parameters including FBS, HOMA-IR, Triglyceride, HDL , SHBG and s. testosterone