Study of Hematological Parameters in Central Nervous System Infections among Pediatric Patients
Keywords:
Hematological Parameters; Central Nervous System(CNS) Infections; Pediatric PatientsAbstract
Background: Central nervous system infections (CNSI) are a known risk factor for the development of acute symptomatic seizures and represent a major risk factor for pediatric patients which cause of morbidity and mortality in children.
Objective: The aim of current study is to interpret the children's hematological parameters related to their central nervous system infection.
Patient and methods: This Cross-sectional prospective study included 101 infants and children who were admitted in Pediatric Neurological ward at CWTH, Baghdad, Iraq from 2020 to 2021. collected data represents information about age, gender, clinical presentation at admission, CSF finding with its gram stain and culture, complete blood cell (CBC) with film and culture (if ordered), neuroimaging finding (whether CT scan or MRI), and lastly if there is any past medical history.
Result: The total numbers of participants were 101 patients where 59 (58%) male more than female 42 (42%) female, the most common presentation Feature was Fever (99 patients or 98%) followed by Vomiting (73 patients or 72.2 %) and seizures (53 patients or 52.5%), Group C has the higher number of patients in compared to group B and C.so results of current study showed significant differences in CSF’s WBCs mean between groups A and B(*P=0.0417), and groups B and C(*P=0.0337), while there is no significant differences between A and C. blood cultures although it is recommended in CNS infection, it has been requested in 52 patient only, also the yield of such cultures was low (just 23% or 12 cultures +ve). Regarding Hematological finding whether Blood WBCs, Neutrophils, Lymphocytes and Platelets. There was no significant differences between groups A, B, C.
Conclusion: CSF infections in male more than female female, so the most common presentation Feature was Fever followed by Vomiting, as well as significant differences in CSF’s WBCs mean between groups A and B(*P=0.0417), and groups B and C(*P=0.0337), while there is no significant differences between A and C. blood cultures although it is recommended in CNS infection, it has been requested in 52 patient only, also the yield of such cultures was low (just 23% or 12 cultures +ve). Also hematological finding whether Blood WBCs, Neutrophils, Lymphocytes and Platelets. There were no significant differences between groups A, B, C
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