Structural and Functional Effect of Impaired Iodine Supply on the Thyroid Gland, Ovaries and Thymus

Authors

  • Bahram J. Mahmoudi, Reza G. Yasmin, Cyrus J. Parinaz

Keywords:

Impaired Iodine Supply, Effect, Structural, Functional, Thyroid Gland, Ovaries

Abstract

Formation and regulation of thyroid metabolism is a topical issue in biology and medicine. The functional orientation of the thyroid gland changes under the influence of environmental pollution, deterioration of social conditions and diet, increased stress, allergization and immunization of the population. In this regard, thyroid pathology is currently becoming increasingly environmentally and socially conditioned. Dynamic structural and functional reactions of the thyroid gland are aimed at stopping the unfavorable factor, but compensatory reserves for maintaining homeostasis are not unlimited. The problem of iodine intake disorders is relevant for many regions globally. The existing clinical and morphological data convince us of the necessity of complex clinical and experimental studies. Ovarian insufficiency is often caused by dysfunction of the thyroid gland, however, the morphological aspects of the disturbance of interrelated processes in the thyroid gland and ovaries are practically unknown. It is extremely difficult to obtain morphological verification in the clinic of a pathological process developing according to a complex scheme of mutual aggravation, with the involvement of interrelated organs and systems, with the imposition of drug pathomorphosis. Few works are devoted to the structural basis of the influence of the thyroid systems of the mother and offspring in the presence of thyroid dysfunction in pregnant women

Downloads

Download data is not yet available.

References

Sun X, Shan Z, Teng W. Effects of increased iodine intake on thyroid disorders. Endocrinol Metab (Seoul). 2014 Sep;29(3):240-7. doi: 10.3803/EnM.2014.29.3.240. PMID: 25309781; PMCID: PMC4192807.

Khudair A, Khudair A, Niinuma SA, Habib H, Butler AE. From deficiency to excess: the impact of iodine excess on reproductive health. Front Endocrinol (Lausanne). 2025 Apr 30;16:1568059. doi: 10.3389/fendo.2025.1568059. PMID: 40370779; PMCID: PMC12074946.

Aceves C, Mendieta I, Anguiano B, Delgado-González E. Molecular Iodine Has Extrathyroidal Effects as an Antioxidant, Differentiator, and Immunomodulator. International Journal of Molecular Sciences. 2021; 22(3):1228. https://doi.org/10.3390/ijms22031228

Mahapatra D, Chandra AK. Biphasic action of iodine in excess at different doses on ovary in adult rats. Journal of Trace Elements in Medicine and Biology. 2017 Jan 1;39:210-20.

Ahad F, Ganie SA. Iodine, Iodine metabolism and Iodine deficiency disorders revisited. Indian J Endocrinol Metab. 2010 Jan;14(1):13-7. PMID: 21448409; PMCID: PMC3063534.

Leung AM, Braverman LE. Consequences of excess iodine. Nat. Rev. Endocrinol. 2014;10:136–142

Lisco G, De Tullio A, Giagulli VA, De Pergola G, Triggiani V. Interference on iodine uptake and human thyroid function by perchlorate-contaminated water and food. Nutrients. 2020 Jun 4;12(6):1669.

Obregon MJ, del Rey FE, de Escobar GM. The effects of iodine deficiency on thyroid hormone deiodination. Thyroid. 2005 Aug 1;15(8):917-29.

Ślebodziński AB. Ovarian iodide uptake and triiodothyronine generation in follicular fluid: The enigma of the thyroid ovary interaction. Domestic animal endocrinology. 2005 Jul 1;29(1):97-103.

Mathews DM, Johnson NP, Sim RG, O'Sullivan S, Peart JM, Hofman PL. Iodine and fertility: do we know enough?. Human Reproduction. 2021 Feb 1;36(2):265-74.

Colella M, Cuomo D, Giacco A, Mallardo M, De Felice M, Ambrosino C. Thyroid hormones and functional ovarian reserve: systemic vs. peripheral dysfunctions. Journal of clinical medicine. 2020 Jun 1;9(6):1679.

Welt CK. Primary ovarian insufficiency: a more accurate term for premature ovarian failure. Clinical endocrinology. 2008 Apr;68(4):499-509.

Piek MW, Postma EL, van Leeuwaarde R, de Boer JP, Bos AM, Lok C, Stokkel M, Filipe MD, van der Ploeg IM. The effect of radioactive iodine therapy on ovarian function and fertility in female thyroid cancer patients: a systematic review and meta-analysis. Thyroid. 2021 Apr 1;31(4):658-68.

Venturi S, Venturi M. Iodine, thymus, and immunity. Nutrition. 2009 Sep 1;25(9):977-9.

Vini L, Hyer S, Al-Saadi A, Pratt B, Harmer C. Prognosis for fertility and ovarian function after treatment with radioiodine for thyroid cancer. Postgraduate medical journal. 2002 Feb;78(916):92-3.

Published

2025-08-03

How to Cite

Bahram J. Mahmoudi, Reza G. Yasmin, Cyrus J. Parinaz. (2025). Structural and Functional Effect of Impaired Iodine Supply on the Thyroid Gland, Ovaries and Thymus. Academic Journal of Clinicians, 7(03), 93–104. Retrieved from https://clinician.site/index.php/ajcs/article/view/180