Ultrastructural and Immunohistochemical Study in Different Types of Neuromuscular Pathology

Abstract

Neuromuscular pathology is polymorphic in its manifestations, which is why difficulties arise in recognizing hereditary forms of neuromuscular diseases and their differential diagnosis. Pathomorphological studies of muscle tissue are of great importance for the diagnosis of hereditary neuromuscular diseases. As a rule, various neuromuscular diseases are characterized by an individual pathomorphological picture, although individual signs in various combinations and with varying degrees of severity can appear in various diseases. Ultrastructural studies are of great importance in elucidating the pathogenesis and diagnosis of diseases. Characteristic changes in the ultrastructure of muscle fibers in a number of neuromuscular diseases have been described. The use of morphological methods for studying biopsy material from skeletal muscles in patients with neuromuscular pathology allows for differential diagnosis between individual forms of progressive muscular dystrophies and denervation amyotrophies, as well as for diagnosing individual forms of structural myopathies. To establish an accurate diagnosis, develop treatment and prevention methods, it is necessary to understand the molecular mechanisms of the occurrence of neuromuscular diseases. In this regard, the study of the expression of certain proteins and components of signaling pathways in human skeletal muscle, the defect of which can lead to pathology, is of considerable interest. The aim of the study is to identify the general patterns of structural reorganization of human skeletal muscle in some types of muscle pathology