Thrombophilia Markers in Cerebrovascular Disorders

Abstract

In the pathogenesis of cerebrovascular disorders, two components are distinguished: systemic and local hemodynamic disorders. Local hemodynamic factors play an important role in the regulation of regional blood circulation and microcirculation as modulators of the vasomotor and hemostatic functions of the endothelium. The peculiarity of the endothelium function in the CNS is determined by its participation in the multilevel system of regulation of cerebral circulation - in the regulation of vascular tone, the aggregate state of blood in the cerebral vessels, proliferation, immune response, migration of blood cells into the vascular wall, synthesis of inflammation mediators, reparation processes and neoangiogenesis. Changes in the hemostasis system are of great importance in the development and course of cerebrovascular disorders, which can determine the early debut of cerebral blood supply insufficiency. laboratory monitoring of the hemostasis state is very important for the successful treatment of patients with such a diagnosis. The tendency to thrombosis, hereditary and acquired, plays a major role in the development and course of cerebrovascular disorders. Arterial thrombosis occurs due to an abnormality of the vascular wall (as a result of atherosclerosis, infectious damage to the endothelium, etc.) and increased activation of platelets. The causes of venous thrombosis are increased blood clotting and stasis. The aim of the study is to establish the role of changes in the hemostasis system and functional activity of the endothelium in the mechanisms of development of acute and chronic cerebrovascular disorders in order to optimize laboratory diagnostics of the severity and outcome of the disease.